October 2022 heralded another crisis for hospitals and physicians: the tripledemic. It likely won’t be the last season for a potential infectious disease calamity, so every healthcare stakeholder must play a role in mitigating the damage. However, issues such as staffing, vaccine fatigue, misinformation, and operational challenges may inhibit successful interventions. Precision’s Maureen Hennessey and Cynthia Miller argue for the need to create a wholistic pandemic strategy that align’s with the Quintuple Aim and supports the five aims: care-team well being, better patient care, healthier people, affordability, and health equity.